{"id":2808,"date":"2025-02-05T13:26:00","date_gmt":"2025-02-05T13:26:00","guid":{"rendered":"https:\/\/ipeace.com\/?p=2808"},"modified":"2025-11-12T05:11:34","modified_gmt":"2025-11-12T05:11:34","slug":"female_o_ipsc","status":"publish","type":"post","link":"https:\/\/ipeace.com\/en\/female_o_ipsc\/","title":{"rendered":"I Peace establishes and offers low immunoreaction risk GMP iPS Cells"},"content":{"rendered":"\n

Three lines of GMP iPS Cells derived from type O female blood are now offered<\/u><\/strong><\/p>\n\n\n\n

as off-the-shelf product<\/u><\/strong><\/p>\n\n\n\n

(Palo Alto, CA) Leading GMP cell CDMO I Peace, Inc. (https:\/\/ipeace.com\/en\/<\/a>), specializing in induced pluripotent stem cells (iPSCs) and iPSC-derived cell therapies, announced that the company has established low immunoreaction risk GMP iPSCs derived from type O female blood and started offering as an off-the-shelf product.<\/p>\n\n\n\n

It is well known that HLA homozygous iPSCs are often selected to reduce adverse immune response in patients, however, there has recently been an increased demand for type O female blood-derived iPSCs. Type O female blood-derived iPSCs have multiple merits including the low immunoreaction risk from ABO blood type and Y chromosome-derived proteins.<\/p>\n\n\n\n

With the offering of these off-the-shelf, low immunoreaction risk iPSCs, I Peace\u2019s iPSC offerings have been enriched to serve a wider variety of cell therapy developers and pharmaceutical companies.<\/p>\n\n\n\n

Advantages of type O blood-derived iPSCs<\/u><\/strong>
Because of the absence of A or B antigens, type O blood donors are considered \u201cuniversal donors\u201d for blood transfusions. Likewise, iPS cells derived from type B lymphocytes demonstrate greater universal compatibility, simplifying the logistics of matching donor cells to recipients.<\/p>\n\n\n\n

Advantages of female donor-derived iPSCs<\/u><\/strong>
Male donors contribute a Y chromosome, which is smaller, contains fewer genes, and is prone to specific genetic instabilities during extended culture or reprogramming processes. This could impact the quality or safety of iPSC-derived therapies. Female donors avoid this risk, potentially leading to greater genetic stability in the iPSC line.<\/p>\n\n\n\n

Proteins encoded by the Y chromosome may also act as antigens and trigger immune responses in female recipients. Female-derived cells lack these antigens, making them more universally applicable. Furthermore, female-derived iPSCs may be preferred for studies or therapies related to female-specific diseases or conditions, as they inherently reflect female physiology.<\/p>\n\n\n\n

I Peace will continue to provide iPSCs and cell-related CDMO services to more companies and institutions to bring iPSC-derived therapies closer to everyone.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Three lines of GMP iPS Cells derived from type O female blood are now offered as off-the-shelf product (Palo Alto, CA) Leading GMP cell CDMO I Peace, Inc. (https:\/\/ipeace.com\/en\/), specializing in induced pluripotent stem cells (iPSCs) and iPSC-derived cell therapies, announced that the company has established low immunoreaction risk GMP iPSCs derived from type O […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[28],"tags":[36,194,217,229,167],"class_list":["post-2808","post","type-post","status-publish","format-standard","hentry","category-press","tag-ipsc","tag-cell-therapy","tag-gmpipsc","tag-female-o-ipsc","tag-ips-cell"],"yoast_head":"\nI Peace establishes and offers low immunoreaction risk GMP iPS Cells | I Peace, Inc<\/title>\n<meta name=\"description\" content=\"I Peace, Inc. has established low immunoreaction risk GMP iPSCs derived from type O female blood and started offering as an off-the-shelf product.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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